CD40 Antibody from BIORBYT LTD.
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| Antigenic Specificity | CD40 |
| Clone | C40/2383 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2b, kappa |
| Format | Protein G purified |
| Size | 20 ug, 100 ug |
| Concentration | n/a |
| Applications | ELISA, FACS, IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD40 is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is expressed on B-lymphocytes, follicular dendritic cells, bone marrow-derived dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zones of secondary lymphoid organs. |
| Immunogen | A portion of amino acids 29-107 from the human protein was used as the immunogen for the CD40 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P25942 |
| Catalog # | orb606660 |
| Price | $405 |
| Order / More Info | CD40 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
BIORBYT LTD.
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P: +44 (0)1223 859 353
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info@biorbyt.com
http://www.biorbyt.com
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Biorbyt LLC
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Email: info@biorbyt.com
Phone: +1 (415) 906-5211
Fax: +1 (415) 651-8558
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