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Antigenic Specificity | Integrin beta 3 |
Clone | 4C3 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | unconjugated |
Size | 100 ul |
Concentration | 1mg/ml |
Applications | WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). |
Immunogen | Purified recombinant human Integrin beta 3(N-terminus) protein fragments expressed in E.coli. |
Other Names | ITGB3; GP3A; Integrin beta-3; Platelet membrane glycoprotein IIIa; GPIIIa; CD antigen CD61 |
Gene, Accession # | Gene ID: 3690, UniProt: P05106 |
Catalog # | orb1732823 |
Price | $345 |
Order / More Info | Integrin beta 3 Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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