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Antigenic Specificity | Cyclin D1 / CCND1 |
Clone | DCS-6 |
Host Species | Mouse |
Reactive Species | human, mouse, rat |
Isotype | IgG2a, kappa |
Format | Protein G purified |
Size | 100 ug, 20 ug |
Concentration | n/a |
Applications | FACS, IF, IHC-P, WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody recognizes a protein of 36kDa, identified as Cyclin D1. It is a putative proto-oncogene overexpressed in a wide variety of human neoplasms and a key cell cycle regulator. This antibody neutralizes the activity of Cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression. Cyclin D1 antibody is useful in identifying mantle cell lymphomas, which stain positive, from CLL/SLL and follicular lymphomas, which stain negative. Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1. |
Immunogen | Human recombinant full length protein was used as the immunogen for this Cyclin D1 antibody. |
Other Names | n/a |
Gene, Accession # | Gene ID: 595 |
Catalog # | orb248183 |
Price | $764 |
Order / More Info | Cyclin D1 / CCND1 Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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