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Antigenic Specificity | BTLA / CD272 |
Clone | BTLA/1528 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1, kappa |
Format | Protein G purified |
Size | 100 ug, 20 ug |
Concentration | n/a |
Applications | ELISA |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | B and T lymphocyte attenuator (BTLA) is an immunoglobulin domain-containing glycoprotein whose expression is induced during T-cell activation. BTLA is similar to CTLA-4 and PD-1, all of which are coinhibitory receptors belonging to the CD28 family. However, unlike CTLA-4 and PD-1, BTLA does not interact with B7-Ig family counter receptors. Rather, the herpesvirus entry mediator (HVEM), a TNF receptor, acts as a molecular switch that modulates T-cell activation by propagating inhibitory signals through BTLA. The BTLAHVEM interaction is conserved between Mouse and human, suggesting that this system is an important pathway regulating lymphocyte activation. |
Immunogen | Recombinant extracellular human CD272/BTLA protein was used as the immunogen for this BTLA antibody. |
Other Names | n/a |
Gene, Accession # | n/a |
Catalog # | orb639611 |
Price | $764 |
Order / More Info | BTLA / CD272 Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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