UHRF1 pairs Antibody from BIORBYT LTD.
Search, find, compare suppliers for anti-UHRF1 pairs antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | UHRF1 pairs |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | affinity purified |
| Size | 100 ul |
| Concentration | 100 µg/ml BSA |
| Applications | WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit polyclonal to UHRF1. UHRF1 antibodies represent a pair of fully characterized antibodies that recognize two different regions of a target protein. The product is developed by Biorbyt to address whether the signal observed truly represents the protein of interest, an often encountered issue in antibody pairs-based assays. The use of a pair of fully characterized vPair antibodies in the same assay can validate signal specificity since vPair antibodies recognize two independent epitopes of the same protein. Different sets of vPair antibodies are developed at Biorbyt to work with specific applications, including antibody pairs arrays, Western blot, IP-Western, ChIP, IHC, and FACS. E3 ubiquitin-protein ligase UHRF1 is a multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. UHRF1 specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, UHRF1 also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, UHRF1 specifically recognizes and binds histone H3 trimethylated at Lys-9 (H3K9me3) and unmethylated at Arg-2 (H3R2me0), respectively, and recruits chromatin proteins. |
| Immunogen | middle region or the C-terminal region of human UHRF1 |
| Other Names | E3 ubiquitin-protein ligase UHRF1 pairs, Inverted CCAAT box-binding protein of 90 kDa pairs, Nuclear protein 95 pairs, Nuclear zinc finger protein Np95 pairs, HuNp95 pairs, hNp95 pairs, RING finger protein 106 pairs, Transcription factor ICBP90 pairs, Ubiquitin-like PHD and RING finger domain-containing protein 1 pairs, hUHRF1 pairs, Ubiquitin-likecontaining PHD and RING finger domains protein 1 pairs, ICBP90 pairs, NP95 pairs, RNF106 pairs |
| Gene, Accession # | UniProt: Q96T88 |
| Catalog # | orb131739 |
| Price | $512 |
| Order / More Info | UHRF1 pairs Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
BIORBYT LTD.
7 Signet Court
Swann Road
Cambridge, CB5 8LA U.K.
P: +44 (0)1223 859 353
F: +44(0)1223 280 240
info@biorbyt.com
http://www.biorbyt.com
U.S. OFFICE
Biorbyt LLC
1100 Corporate Square Drive
Helix Center, Suite 221
St Louis, MO 63132
Email: info@biorbyt.com
Phone: +1 (415) 906-5211
Fax: +1 (415) 651-8558
Profile of BIORBYT LTD.
Return to Antibodies