SLAMF7 / CS1 Antibody from BIORBYT LTD.
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|---|---|
| Antigenic Specificity | SLAMF7 / CS1 |
| Clone | SLAMF7/3649 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1, kappa |
| Format | Protein G purified |
| Size | 20 ug, 100 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CS1, also known as novel Ly9, SLAMF7, 19A24 or CRACC, is a homophilic cell surface receptor. It is a member of the SLAM (signaling lymphocytic activation molecule) family of receptors expressed on natural killer (NK) cells, T cells and stimulated B cells. CS1 contains immunoreceptor tyrosine-based switch motifs in its cytoplasmic domain but, unlike other SLAM receptors, it does not recruit SAP (SLAM-associated protein). In humans, CS1 activates NK cells through an EAT-2-mediated pathway that is SAP-independent. CS1 recruits and associates with EAT-2, a protein closely related to SAP. EAT-2 induces phosphorylation of CS1 which then, upon ligand binding, activates downstream cytotoxicity effectors PLC and PI 3K. In mice, the EAT-2 association with CS1 has an inhibitory effect on the activation of NK cells. |
| Immunogen | A portion of amino acids 249-335 from the human protein was used as the immunogen for the SLAMF7 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: Q9NQ25 |
| Catalog # | orb699578 |
| Price | $405 |
| Order / More Info | SLAMF7 / CS1 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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