TIM-3 / HAVCR2 Antibody from BIORBYT LTD.
Search, find, compare suppliers for anti-TIM-3 / HAVCR2 antibody, protein, ELISA kits.
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|---|---|
| Antigenic Specificity | TIM-3 / HAVCR2 |
| Clone | TIM3/4025 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2b, kappa |
| Format | Protein G purified |
| Size | 20 ug, 100 ug |
| Concentration | n/a |
| Applications | IHC-P, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | TIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. TIM-3 is expressed on the surface of effector T cel tonsil, lymph node or spleen. ls (CD4+Th1 and CD8+Tc1) but not on helper T cells (CD4+Th2 and CD8+Tc2). In chronic inflammation, autoimmune disorders, and some cancers, TIM-3 is upregulated on several other hematopoietic cell types. The Ig domain of TIM-3 interacts with a ligand on resting but not activated Th1 and Th2 cells. The glycosylated Ig domain of TIM-3 binds cell-associated galectin-9. This induces TIM-3 Tyr phosphorylation and pro-apoptotic signaling. TIM-3 functions as a negative regulator of Th1 cell activity. Its blockade results in increased IFN-gamma production, Th1 cell proliferation and cytotoxicity, regulatory T cell development, and increases in macrophage and neutrophil infiltration into sites of inflammation. |
| Immunogen | A portion of amino acids 22-202 from the human protein was used as the immunogen for the TIM3 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: Q8TDQ0 |
| Catalog # | orb699821 |
| Price | $405 |
| Order / More Info | TIM-3 / HAVCR2 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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