p53 / TP53 Antibody from BIORBYT LTD.
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| Antigenic Specificity | p53 / TP53 |
| Clone | rTP53/8993 |
| Host Species | Recombinant Mouse |
| Reactive Species | human |
| Isotype | IgG1, kappa |
| Format | unconjugated |
| Size | 20 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Recognizes a 53kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 protein. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma. |
| Immunogen | Recombinant human full-length protein was used as the immunogen for the recombinant TP53 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P04637 |
| Catalog # | orb1825215 |
| Price | $405 |
| Order / More Info | p53 / TP53 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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