GITR / TNFRSF18 Antibody from BIORBYT LTD.
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| Antigenic Specificity | GITR / TNFRSF18 |
| Clone | DTA-1 |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG2b, lambda |
| Format | Protein G purified |
| Size | 20 ug, 100 ug |
| Concentration | n/a |
| Applications | FACS, IF |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+ CD4+ Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-kB activation, and abrogate the inhibitory function of CD25+ CD4+ Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response. |
| Immunogen | Mouse CD25+ CD4+ T cells were used as the immunogen for the GITR antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: O35714 |
| Catalog # | orb749934 |
| Price | $405 |
| Order / More Info | GITR / TNFRSF18 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
BIORBYT LTD.
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