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Antigenic Specificity | Vimentin |
Clone | VIM/4388R |
Host Species | Recombinant Rabbit |
Reactive Species | human |
Isotype | IgG |
Format | Protein A purified |
Size | 100 ug, 20 ug |
Concentration | n/a |
Applications | IHC-P |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This MAb reacts with a 58kDa protein identified as vimentin. It shows no cross-reaction with other closely related intermediate filament proteins (IFP s) such as desmin, keratin, neurofilament, and glial fibrillary acid protein. Anti-vimentin alone is of limited value as a diagnostic tool; however, when used in panels with other antibodies, it is useful for the sub-classification of a given tumor. Expression of vimentin, when used in conjunction with anti-keratin, is helpful when distinguishing melanomas from undifferentiated carcinomas and large cell lymphomas. All melanomas and Schwannomas react strongly with anti-vimentin. It labels a variety of mesenchymal cells, including melanocytes, lymphocytes, endothelial cells, and fibroblasts. Non-reactivity of anti-vimentin is often considered more useful than its positive reactivity, since there are a few tumors that do not contain vimentin, e.g. hepatoma and seminoma. Anti-vimentin is also useful as a tissue process control reagent. |
Immunogen | A portion of amino acids 366-466 from the human protein was used as the immunogen for the recombinant Vimentin antibody. |
Other Names | n/a |
Gene, Accession # | UniProt: P08670 |
Catalog # | orb699805 |
Price | $764 |
Order / More Info | Vimentin Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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