Ku80 / XRCC5 Antibody from BIORBYT LTD.
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| Antigenic Specificity | Ku80 / XRCC5 |
| Clone | XRCC5/7314 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1, kappa |
| Format | unconjugated |
| Size | 20 ug |
| Concentration | n/a |
| Applications | IHC-P, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The Ku protein is localized in the nucleus and is composed of subunits referred to as Ku-70 (or p70) and Ku-86 or (p86) which is also known by the synonym Ku-80 or (p80). Ku was first described as an autoantigen to which antibodies were produced in a patient with scleroderma-polymyositis overlap syndrome, and was later found in the sera of patients with other rheumatic diseases. Ku has several functions, including cell signaling, DNA replication and transcriptional activation. Ku is involved in Pol II-directed transcription by virtue of its DNA binding activity; serving as the regulatory component of the DNA-associated protein kinase that phosphorylates Pol II and transcription factor Sp. Ku proteins also activate transcription from the U1 small nuclear RNA and the human transferrin receptor gene promoters. |
| Immunogen | A recombinant partial protein sequence (within amino acids 300-500) from the human protein was used as the immunogen for the XRCC5 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P13010 |
| Catalog # | orb1823778 |
| Price | $405 |
| Order / More Info | Ku80 / XRCC5 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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