ICOS-L / ICOS Ligand / B7RP-1 Antibody from BIORBYT LTD.
Search, find, compare suppliers for anti-ICOS-L / ICOS Ligand / B7RP-1 antibody, protein, ELISA kits.
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|---|---|
| Antigenic Specificity | ICOS-L / ICOS Ligand / B7RP-1 |
| Clone | ICOSL/3260 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2b, kappa |
| Format | Protein G purified |
| Size | 100 ug, 20 ug |
| Concentration | n/a |
| Applications | ELISA, IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This MAb recognizes a protein of 36kDa, identified as ICOS-L. It is a ligand for the ICOS receptor that initiates T and B cell proliferation and cytokine secretion. ICOS-L interactions play an essential role in T cell-dependent B cell activation in peripheral lymphoid organs such as spleen and lymph nodes. ICOS-L protein is present in myeloid leukocytes, and by Northern blot there are 2.4, 3.0, and 7.0 kb transcripts in brain, heart, kidney, and liver, with lower expression in colon and thymus, and a 1.1 kb transcript in leukocytes. Tumor necrosis factor alpha (TNF), granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) enhance its expression. LPS-induced up-regulation of ICOS-L is dependent on the MyD88-dependent signaling pathway. |
| Immunogen | A recombinant human partial protein (amino acids 23-149) was used as the immunogen for the ICOS Ligand antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: O75144 |
| Catalog # | orb639659 |
| Price | $764 |
| Order / More Info | ICOS-L / ICOS Ligand / B7RP-1 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
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