EIF2A Antibody from BIORBYT LTD.
Search, find, compare suppliers for anti-EIF2A antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | EIF2A |
| Clone | polyclonal |
| Host Species | n/a |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | unconjugated |
| Size | 200 ul, 100 ul, 50 ul |
| Concentration | n/a |
| Applications | WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit polyclonal antibody to EIF2A. Phosphorylation of the eukaryotic initiation factor 2 (eIF2) alpha subunit is a welldocumented mechanism to downregulate protein synthesis under a variety of stress conditions. eIF2 binds GTP and MettRNAi and transfers MettRNA to the 40S subunit to form the 43S preinitiation complex (1,2). eIF2 promotes a new round of translation initiation by exchanging GDP for GTP, a reaction catalyzed by eIF2B (1,2). Kinases that are activated by viral infection (PKR), endoplasmic reticulum stress (PERK/PEK), amino acid deprivation (GCN2), or heme deficiency (HRI) can phosphorylate the alpha subunit of eIF2 (3,4). This phosphorylation stabilizes the eIF2GDPeIF2B complex and inhibits the turnover of eIF2B. Induction of PKR by IFN and TNF alpha induces potent phosphorylation of eIF2 alpha at Ser51 |
| Immunogen | Recombinant fusion protein of human eIF2α(NP_004085.1). |
| Other Names | EIF2S1, EIF2, EIF2A, EIF2alpha, EIF2, EIF2A |
| Gene, Accession # | UniProt: P05198 |
| Catalog # | orb153846 |
| Price | $490 |
| Order / More Info | EIF2A Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
BIORBYT LTD.
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Email: info@biorbyt.com
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