CDK5RAP3 Antibody from BIORBYT LTD.
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| Antigenic Specificity | CDK5RAP3 |
| Clone | monoclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | IgG |
| Format | unconjugated |
| Size | 100 ul |
| Concentration | 1mg/ml |
| Applications | IHC, IP, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629). |
| Immunogen | A synthetic peptide of human CDK5RAP3 |
| Other Names | C53; IC53; LZAP; HSF-27; MST016; PP1553; OK/SW-cl.114 |
| Gene, Accession # | Gene ID: 80279, UniProt: Q96JB5 |
| Catalog # | orb1732385 |
| Price | $345 |
| Order / More Info | CDK5RAP3 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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