FKBP52 Antibody from BIORBYT LTD.
Search, find, compare suppliers for anti-FKBP52 antibody, protein, ELISA kits.
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| Antigenic Specificity | FKBP52 |
| Clone | Hi52C |
| Host Species | Mouse |
| Reactive Species | canine, hamster, human, mouse, rat |
| Isotype | IgG2a |
| Format | ATTO-594 conjugate |
| Size | 100 ug |
| Concentration | 1 mg/ml |
| Applications | ICC, IHC, IP, WB |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Mouse monoclonal to FKBP52 (ATTO-594). Hsp90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones. One class of Hsp90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an Hsp90 binding site. Among the TPR co-chaperones of Hsp90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin A-binding families of immunophilins. FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex. The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the Hsp90. Although FKBP52 and FKBP51 share 75% sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different Hsp90-binding characteristics (3, 5). Also, whereas FKBP51 typically has a role with the progesterone receptor, FKBP52 has been found to be linked to the progesterone, androgen and glucocorticoid receptors.. |
| Immunogen | Synthetic peptide corresponding to the residues of human FKBP52 |
| Other Names | FK506 binding protein 4, FKBP4, FKBP59, HBI, HSP56, p52, p59, PPIase, Rotamase, T cell FK506 binding protein |
| Gene, Accession # | Gene ID: 2288, UniProt: Q02790 |
| Catalog # | orb147204 |
| Price | $593 |
| Order / More Info | FKBP52 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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