Histone H3 (pSer10) Antibody from BIORBYT LTD.
Search, find, compare suppliers for anti-Histone H3 (pSer10) antibody, protein, ELISA kits.
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| Antigenic Specificity | Histone H3 (pSer10) |
| Clone | PHH3/471R |
| Host Species | Recombinant Mouse |
| Reactive Species | human |
| Isotype | IgG2a, kappa |
| Format | Protein G purified |
| Size | 20 ug, 100 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Phosphohistone H3 (PHH3) is a marker specific for cells undergoing mitosis. Serine 10 of Histone H3 is phosphorylated in association with mitotic chromatin condensation in late G2 and M phase of the cell cycle and thus, PHH3 can distinguish mitosis from apoptotic nuclei. The range of percentage PHH3 positive tumor nuclei was from 0.0 to 6.6% (median value 0.8%). Increased expression of PHH3 was significantly associated with tumor thickness (p = 0.031), presence of tumor ulceration (p =0.041) and tumor necrosis (p =0.027), but not with Clarks level of invasion. High levels of PHH3 was associated with increased mitotic count (p = 0.003) and high Ki-67 expression (p = 0.002). For central nervous system tumors, melanoma, soft tissue tumors, GIST, etc., PHH3 mAb is helpful for tumor pathological classification and prognosis. |
| Immunogen | A synthetic peptide corresponding to the amino acids surrounding phospho S10 were used as the immunogen for the recombinant PHH3 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P68431 |
| Catalog # | orb699714 |
| Price | $405 |
| Order / More Info | Histone H3 (pSer10) Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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