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Antigenic Specificity | CD2 |
Clone | TS1/8 |
Host Species | n/a |
Reactive Species | human |
Isotype | IgG1 kappa |
Format | allophycocyanin (APC) conjugate |
Size | 100 tests |
Concentration | n/a |
Applications | FC |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD2 belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection. |
Immunogen | Cytotoxic T lymphocytes |
Other Names | T11, LFA-2, SRBC |
Gene, Accession # | Gene ID: 914, UniProt: P06729 |
Catalog # | orb1881230 |
Price | $439 |
Order / More Info | CD2 Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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