TIA-1 / T-Cell Intracellular Antigen-1 Antibody from BIORBYT LTD.
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| Antigenic Specificity | TIA-1 / T-Cell Intracellular Antigen-1 |
| Clone | rTIA1/1353 |
| Host Species | Recombinant Mouse |
| Reactive Species | human |
| Isotype | IgG1, kappa |
| Format | unconjugated |
| Size | 100 ug |
| Concentration | n/a |
| Applications | IHC-P |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The T cell intracellular antigen 1 (TIA 1) is a 17 kDa cytoplasmic granule associated protein also designated as GMP 17, for granule membrane protein of 17 kDa. The GMP 17/TIA 1 molecule is expressed in cells possessing cytolytic potential and could be involved in the signaling cascade of Fas (CD95) mediated apoptosis. Within hematopoietic cell lines, the rTIA1/1353 monoclonal antibody (mAb) reacts with about 90% of CD16+, 50 60% of CD8+, and less than 10% of CD4+ normal peripheral blood lymphocytes. It reacts with almost all monocytes and granulocytes. This antibody also reacts with CD4+ activated T cell clones, activated NK cell clones, and Con activated thymocytes, but not with B lymphocytes or B cell lines. TIA1 antibody labels cytotoxic T cells and natural killer cells (NK cells). It is also expressed in T-cell lymphoma, large granular lymphocyte (LGL) leukemia and hairy cell leukemia. TIA1 expression in T-cell malignancies may help in differentiating LGL leukemia (high expression) from T-cell lymphocytosis and other T-cell diseases (low expression). TIA1 may also be used to label tumor-infiltrating lymphocytes in the study of immune response to malignancies. |
| Immunogen | Recombinant full-length human protein was used as the immunogen for the T-Cell Intracellular Antigen-1 antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P31483 |
| Catalog # | orb1716151 |
| Price | $764 |
| Order / More Info | TIA-1 / T-Cell Intracellular Antigen-1 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
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