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Antigenic Specificity | SOX11 |
Clone | SOX11/3235R |
Host Species | Recombinant Rabbit |
Reactive Species | human |
Isotype | IgG, kappa |
Format | Protein A purified |
Size | 100 ug, 20 ug |
Concentration | n/a |
Applications | IHC-P |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recognizes a protein of ~47kDa, identified as SOX11. This MAb is highly specific and does not cross-react with other members of the SOX-family. Mantle cell lymphoma (MCL) accounts for 5% to 10% of mature B-cell neoplasms and is an aggressive disease genetically characterized by overexpression of Cyclin D1. Cyclin D1 overexpression is the hallmark of MCL. However, approximately 5%-10% of MCLs lack Cyclin D1 expression and may be misdiagnosed. Almost all Cyclin D1-positive as well as Cyclin D1-negative MCL, show overexpression of SOX-11. The detection of this transcription factor is a useful biomarker for identifying true cyclin D1-negative MCL. |
Immunogen | A portion of amino acids 300-400 from the human protein was used as the immunogen for the recombinant SOX11 antibody. |
Other Names | n/a |
Gene, Accession # | UniProt: P35716 |
Catalog # | orb699754 |
Price | $764 |
Order / More Info | SOX11 Antibody from BIORBYT LTD. |
Product Specific References | n/a |
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