Fas / CD95 Antibody from BIORBYT LTD.
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| Antigenic Specificity | Fas / CD95 |
| Clone | B-R18 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1, kappa |
| Format | Protein G purified |
| Size | 100 ug, 20 ug |
| Concentration | n/a |
| Applications | FACS, Functional Studies, IF, IHC-Fr |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | mAb B-R18 specifically recognizes CD95, also known as Fas, a transmembrane glycoprotein with a MW of 40-45kDa, containing 8kDa of N-glycosidic-linked polysaccharide. It is a receptor for TNFSF6/FASLG, a member of the nerve growth factor receptor/tumor necrosis factor superfamily, mediating receptor-triggered apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation, which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). CD95 antigen is expressed on the surface of various cell types, preferentially on the CD45RAlow CD45ROhigh subset of memory T lymphocytes. |
| Immunogen | Recombinant human protein was used as the immunogen for the Fas antibody. |
| Other Names | n/a |
| Gene, Accession # | UniProt: P25445 |
| Catalog # | orb749603 |
| Price | $764 |
| Order / More Info | Fas / CD95 Antibody from BIORBYT LTD. |
| Product Specific References | n/a |
BIORBYT LTD.
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