Gamma Catenin / Plakoglobin Antibody from BIORBYT LTD.

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Antigenic SpecificityGamma Catenin / Plakoglobin
Clonemonoclonal
Host SpeciesMouse
Reactive Specieshuman, mouse
IsotypeIgG1, kappa
FormatProtein G purified
Size100 ug, 20 ug
Concentrationn/a
ApplicationsFACS, IF, WB
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DescriptionIt recognizes a protein of 80-87kDa, identified as gamma-Catenin or Plakoglobin. The catenins (α, β, γ and δ) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. α T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantly expressed in cardio-myocytes and in the peritubular myoid cells of the testis. α T-catenin binds to α E-catenin as well as to β-catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for α-T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer s disease (LOAD) as well as to dilated cardiomyopathy.
ImmunogenRecombinant full length human gamma Catenin fused to maltose binding protein was used as the immunogen for the Plakoglobin antibody. The epitope has been found to be in the N-terminal region.
Other Namesn/a
Gene, Accession #UniProt: P14923
Catalog #orb639493
Price$764
Order / More InfoGamma Catenin / Plakoglobin Antibody from BIORBYT LTD.
Product Specific Referencesn/a
BIORBYT LTD.
BIORBYT LTD.
BIORBYT LTD.
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Swann Road
Cambridge, CB5 8LA U.K.
P: +44 (0)1223 859 353
F: +44(0)1223 280 240

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