PARP Antibody from BIOVISION, INC.

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Antigenic SpecificityPARP
Clonepolyclonal
Host SpeciesRabbit
Reactive Speciesmouse
Isotypen/a
Formataffinity purified
Size100 µg
Concentration0.5 mg/ml
ApplicationsWestern blot, Immunocytochemistry. RUO
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DescriptionRabbit anti-PARP (Cleaved) Antibody. Lot# 50941. PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apoptosis response of cells. This protein can be cleaved by many caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. The cleavege occurs between ASP214 and Gly 215, which separates PARP's N-terminal DNA binding domain (24 kDa) from its C-terminal catalytic domain (89 kDa). It has been shown that cleavage of PARP facilitates cellular disassembly and inhibition of PARP cleavage attenuates apoptosis in vitro.
ImmunogenSynthetic peptide corresponding to the C-terminus adjacent to Asp214 of mouse PARP
Other NamesPARP1, ADPRT, PPOL, NAD(+) ADP-ribosyltransferase 1
Gene, Accession #Gene ID: 11545, Accession: NP 031441
Catalog #3141-100
Price$365
Order / More InfoPARP Antibody from BIOVISION, INC.
Product Specific Referencesn/a
BIOVISION, INC.
BIOVISION, INC.
BIOVISION, INC.
155 S. Milpitas Boulevard
Milpitas CA 95035
P: 408-493-1800
P: 800-891-9699
F: 408-493-1801

support@biovision.com

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