BACE2 Antibody from BIOVISION, INC.

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Antigenic SpecificityBACE2
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse, rat
Isotypen/a
Formatpeptide affinity purified
Size100 µg
Concentration05 mg/ml
ApplicationsWestern blot
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DescriptionPolyclonal antibody to detect BACE2/Asp1 in human samples. Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-soµght beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1. BACE2 also cleaves APP at beta-site and at a different site within Abeta. BACE2 locates on chromosome 21q22.3, the so-called 'Down critical region', sµggesting that BACE2 and Abeta may also contribute to the pathogenesis of Down syndrome.
ImmunogenA synthetic peptide corresponding to the amino acids 44 to 59 of human BACE2.
Other NamesBACE2, Asp1
Gene, Accession #Gene ID: 25825, Accession: Q9Y5Z0
Catalog #6102-100
Price$295
Order / More InfoBACE2 Antibody from BIOVISION, INC.
Product Specific Referencesn/a
BIOVISION, INC.
BIOVISION, INC.
BIOVISION, INC.
155 S. Milpitas Boulevard
Milpitas CA 95035
P: 408-493-1800
P: 800-891-9699
F: 408-493-1801

support@biovision.com

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