CHRNE (immunotoxin) Antibody from CREATIVE BIOLABS, INC.
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| Antigenic Specificity | CHRNE (immunotoxin) |
| Clone | monoclonal |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | n/a |
| Format | Pseudomonas exotoxin conjugate |
| Size | n/a |
| Concentration | n/a |
| Applications | Cytotoxicity assay, Functional assay, |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | anti-CHRNE immunotoxin (Fab)-PE. This immunotoxin was achieved by conjugating/fusing the Anti-CHRNE Fab to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to Rhabdomyosarcomas (RMS) cells and enters cells by receptor-mediated endocytosis, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treatment of Rhabdomyosarcomas (RMS). |
| Immunogen | n/a |
| Other Names | CHRNE; cholinergic receptor, nicotinic, epsilon (muscle); ACHRE; CMS1D; CMS1E; CMS2A; FCCMS; SCCMS; acetylcholine receptor subunit epsilon; AchR epsilon subunit; acetylcholine receptor, nicotinic, epsilon (muscle); cholinergic receptor, nicotinic, epsilon polypeptide; Rhabdomyosarcomas; RMS; Pseudomonas exotoxin; Pseudomonas exotoxin A; Pseudomonas aeruginosa exotoxin; Pseudomonas aeruginosa exotoxin A; PE; PE38; PE40; ETA; PE33; PE35 |
| Gene, Accession # | UniProt: Q04844 |
| Catalog # | AGTO-L054E |
| Price | please inquire |
| Order / More Info | CHRNE (immunotoxin) Antibody from CREATIVE BIOLABS, INC. |
| Product Specific References | n/a |
CREATIVE BIOLABS, INC.
CREATIVE BIOLABS, INC.
Suite 203
17 Ramsey Road
Shirley NY 11967
P: 1-631-416-1478
F: 1-631-207-8356
info@creative-biolabs.com
http://www.creative-biolabs.com
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