IGHV1-69 Antibody from CREATIVE BIOLABS, INC.
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| Antigenic Specificity | IGHV1-69 |
| Clone | monoclonal |
| Host Species | Recombinant Human |
| Reactive Species | n/a |
| Isotype | n/a |
| Format | unconjugated |
| Size | n/a |
| Concentration | n/a |
| Applications | ELISA; ADCC; CDC; FuncS; |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Recombinant Anti-IGHV1-69 Antibody (V3S-0723-FY105). This HuG6.3 product is a recombinant human antibody,which recognizes human IGHV1-69. The humanized antibody HuG6.3 exhibited approximately a 2-fold increase in binding affinity for G6-id(+) antibodies compared to the original MuG6. HuG6.3 was capable of killing cells expressing G6-id(+) BCR and patient B-CLL cells through antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). Furthermore, both MuG6 and HuG6.3 were found to facilitate the in vivo depletion of B-CLL cells in NSG mice. These findings suggest that HuG6.3 may offer a novel precision medicine approach for selectively eliminating IGHV1-69-encoding G6-id(+) B-CLL cells. |
| Immunogen | n/a |
| Other Names | IGHV1-69; Immunoglobulin Heavy Variable 1-69; IGHV1-E; IGHV1E; Immunoglobulin Heavy Variable 1-E |
| Gene, Accession # | n/a |
| Catalog # | V3S-0723-FY105 |
| Price | please inquire |
| Order / More Info | IGHV1-69 Antibody from CREATIVE BIOLABS, INC. |
| Product Specific References | n/a |
CREATIVE BIOLABS, INC.
CREATIVE BIOLABS, INC.
Suite 203
17 Ramsey Road
Shirley NY 11967
P: 1-631-416-1478
F: 1-631-207-8356
info@creative-biolabs.com
http://www.creative-biolabs.com
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