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Antigenic Specificity | IgE |
Clone | monoclonal |
Host Species | Recombinant Mouse |
Reactive Species | human |
Isotype | n/a |
Format | unconjugated |
Size | n/a |
Concentration | n/a |
Applications | WB, ELISA, IP, FC, FuncS, Neut, IF, |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Anti-Human IGHE Recombinant Antibody (Omalizumab). Recombinant monoclonal antibody to Human IgE. Omalizumab is a recombinant DNA-derived humanized IgG1k monoclonal antibody that specifically binds to free human immunoglobulin E (IgE) in the blood and interstitial fluid and to membrane-bound form of IgE (mIgE) on the surface of mIgE-expressing B lymphocytes. Unlike an ordinary anti-IgE antibody, omalizumab does not bind to IgE that is already bound by the high affinity IgE receptor (FcεRI) on the surface of mast cells, basophils, and antigen-presenting dendritic cells. IgE is commonly involved in type I hypersensitivity, which manifests the most prevalent allergic diseases. It has been estimated that as high as 20 to 40% of the populations who live a western lifestyle in economically advanced countries are affected by allergy and seek medical help. In the U.S., 8% of adults and 10% of children have asthma. While allergy occurs more frequently in individuals with higher serum IgE levels, such a correlation is only statistical and not absolute. Some allergic individuals have very low serum IgE, and some people with very high IgE have no allergic problems. |
Immunogen | The details of the immunogen for this antibody are not available. |
Other Names | Omalizumab;omalizumab;242138-07-4;DB00043IGHE;Immunoglobulin heavy constant epsilon; |
Gene, Accession # | n/a |
Catalog # | TAB-007 |
Price | please inquire |
Order / More Info | IgE Antibody from CREATIVE BIOLABS, INC. |
Product Specific References | n/a |