CHIKV E2 Antibody from CREATIVE BIOLABS, INC.
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| Edit | |
|---|---|
| Antigenic Specificity | CHIKV E2 |
| Clone | monoclonal |
| Host Species | Recombinant Human |
| Reactive Species | CHIKV |
| Isotype | n/a |
| Format | unconjugated |
| Size | n/a |
| Concentration | n/a |
| Applications | Neut, FRNT, FuncS, |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Human Anti-CHIKV E2 Recombinant Antibody (clone ch-CHK-152 N297Q). A chimeric mouse-human ch-CHK-152 N297Q, an aglycosyl variant, was derived from murine antibody CHK-152, which lacks the ability to engage C1q or Fc-γ receptors; this mutation does not affect the ability to bind the neonatal Fc receptor (FcRn) or half-life of antibody in mouse serum. The affinity of ch-CHK-152 N297Q binding to purified pE2-E1 was measured by surface plasmon resonance (SPR) and compared to the parent murine MAb. Notably, ch-CHK-152 N297Q and the murine CHK-152 all had similar affinity (KD of 3 to 4 nM) and neutralizing activity in cell culture (Fig. 4B). As expected, ch-CHK-152 N297Q failed to bind efficiently to soluble Fc-γ receptors or C1q. |
| Immunogen | Adult C57BL/6 mice deficient for interferon regulatory factor 7 (Irf7 −/−) were infected with the La Reunion 2006 OPY-1 strain of CHIKV (CHIKV-LR). These mice were boosted with CHIK virus-like particles, soluble recombinant CHIKV E2 protein, or live CHIKV-LR. |
| Other Names | Chikungunya virus E2 protein |
| Gene, Accession # | n/a |
| Catalog # | HPAB-S0185-YC |
| Price | please inquire |
| Order / More Info | CHIKV E2 Antibody from CREATIVE BIOLABS, INC. |
| Product Specific References | n/a |
CREATIVE BIOLABS, INC.
CREATIVE BIOLABS, INC.
Suite 203
17 Ramsey Road
Shirley NY 11967
P: 1-631-416-1478
F: 1-631-207-8356
info@creative-biolabs.com
http://www.creative-biolabs.com
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