Edit |   |
---|---|
Antigenic Specificity | EGFR + HER2 Tandem Fab-ABR (bispecific immunotoxin) |
Clone | monoclonal |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | n/a |
Format | bispecific immunotoxin |
Size | n/a |
Concentration | n/a |
Applications | FuncS; Promising therapeutic agent; |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recombinant Human Anti-EGFR x Human Anti-HER2 Tandem Fab-ABR immunotoxin (Bispecific Immunotoxin). Recombinant Anti-EGFR x Anti-HER2 Tandem Fab-ABR immunotoxin (Bispecific Immunotoxin) is designed to be expressed as the abrin-a A chain (ABRa-A) fused to a tandem Fab recognizing EGFR and HER2. It contains three chains and a His-tag at the C/N terminus for affinity purification. The two Fd regions are connected by a flexible linker. This bispecific immunotoxin can deliver ABRa-A to antigen-specific cells. Then ABR is a type II ribosome inactivating protein (RIP) and can kill the target cells. The bispecific immunotoxin is designed for the research of Breast cancer; Colon cancer; Lung cancer; Pancreatic cancer; Gastric cancer; Solid tumors therapy. |
Immunogen | n/a |
Other Names | EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog |
Gene, Accession # | UniProt: P00533 |
Catalog # | BSFAB-ABR027 |
Price | please inquire |
Order / More Info | EGFR + HER2 Tandem Fab-ABR (bispecific immunotoxin) Antibody from CREATIVE BIOLABS, INC. |
Product Specific References | n/a |