CSN3 Antibody from FORTIS LIFE SCIENCES

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Antigenic SpecificityCSN3
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, (presumed: mouse, rat, Xenopus tropicalis, chicken, bovine, orangutan)
Isotypen/a
Formatantigen affinity purified
Size100 µl
Concentration1000 µg/ml
ApplicationsWB, IHC
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DescriptionRabbit anti-CSN3 Antibody, Affinity Purified. CSN3 is one of eight subunits (CSN1 to 8) of the highly conserved COP9 signalsome (CSN) complex originally identified as a regulator of light-mediated development in Arabidopsis. Characterization of CSN from yeast to mammals reveals its function as a modulator of signal transduction pathways involved in a variety of cellular and developmental processes. One of the major functions of the CSN is the regulation of protein degradation via intersection with the ubiquitin-proteasome pathway and regulation of E3-ubiquitin ligases. The CSN also possesses kinase activity. CSN3 is the kinase associated with the CSN complex that phosphorylates signal transducers such as I-kappa-Balpha, p105, and c-Jun. Human CSN3 maps to the Smith-Magenis syndrome locus. Microdeletions in this locus results in mental retardation, skeletal abnormalities, sleep disorder, and neurobehavior anomalies.
ImmunogenEpitope: between 325 and 375
Other NamesSGN3; signalosome subunit 3; JAB1-containing signalosome subunit 3; COP9 signalosome complex subunit 3; COP9 constitutive photomorphogenic homolog subunit 3; COP9 complex subunit 3; CSN3
Gene, Accession #Gene ID: 8533, Accession: NP_003644.2, UniProt: Q9UNS2
Catalog #A300-012A
Price$433
Order / More InfoCSN3 Antibody from FORTIS LIFE SCIENCES
Product Specific Referencesn/a
FORTIS LIFE SCIENCES
FORTIS LIFE SCIENCES
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