ErbB4 Antibody from FORTIS LIFE SCIENCES
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| Antigenic Specificity | ErbB4 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | antigen affinity purified |
| Size | 10 µl |
| Concentration | 1000 µg/ml |
| Applications | IP |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit anti-ErbB4 Antibody, Affinity Purified. ErbB4 is a member of the receptor tyrosine kinase family of proteins. The four members of this family are ErbB1 (Epidermal growth factor receptor; EGFR/HER1), ErbB2 (HER2/Neu), ErbB3 (HER3), and ErbB4 (HER4). The ErbB receptor members are single-pass transmembrane proteins with an extracellular ligand-binding domain and a cytoplasmic tyrosine-kinase domain. The epidermal growth factor (EGF) and its related proteins serve as the ligands for the ErbB receptors. Upon binding, the receptors homo- or heterodimerize, autophosphorylate and make contact with adapter molecules to transmit cellular signals involved in cell proliferation, survival, and differentiation. The ligands preferred by ErbB4 include neuregulins (NRG-2 and NRG-3), heparin-binding EGF-like growth factor, and betacellulin, and epiregulin. ErbB4 appears to be important to mammary gland development and lactation; however its role in breast cancer has not been unequivocally determined. |
| Immunogen | Epitope: between 1100 and 1150 |
| Other Names | proto-oncogene-like protein c-ErbB-4; v-erb-a erythroblastic leukemia viral oncogene homolog 4; p180erbB4; receptor tyrosine-protein kinase erbB-4; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4; HER4; ERBB4 transcript variant I20DEL; ERBB4 transcript variant I12DEL; avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; ALS19; tyrosine kinase-type cell surface receptor HER4; human epidermal growth factor receptor 4 |
| Gene, Accession # | Gene ID: 2066, Accession: NP_005226.1, UniProt: Q15303 |
| Catalog # | A300-666A-T |
| Price | $121 |
| Order / More Info | ErbB4 Antibody from FORTIS LIFE SCIENCES |
| Product Specific References | n/a |
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