NP95/UHRF1 Antibody from FORTIS LIFE SCIENCES
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| Antigenic Specificity | NP95/UHRF1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | antigen affinity purified |
| Size | 100 µl |
| Concentration | 200 µg/ml |
| Applications | WB, IP, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit anti-NP95/UHRF1 Antibody, Affinity Purified. NP95/UHRF1 was originally identified as ICBP90 (inverted CCAAT box-binding protein of 90 kDa) in a one-hybrid screen for proteins that bind the topoisomerase IIalpha gene promoter. NP95/UHRF1 is a heterochromatin binding protein that directly interacts with histones and has proposed roles in the DNA damage response, heterochromatin formation, and cell replication. Structurally, NP95/UHRF1 contains an ubiquitin-like domain (NIRF_N), a plant homeodomain (PHD), a SRA domain, and a RING domain. The RING domain imparts ubiquitin E3 ligase activity that is histone-specific. This E3 ligase activity is proposed to be important to tumor growth. NP95/UHRF1 expression begins in the G1/S phase and continues through mitosis. It has been shown to be required for entry from G1/G0 as well as the G1/S transition in some cell types. NP95/UHRF1 has been found to be part of the pericentric heterochromatin duplication body (pHDB) and involved in the replication and formation of heterochromatin. |
| Immunogen | Epitope: between 275 and 325 |
| Other Names | RNF106; Ubiquitin-like-containing PHD and RING finger domains protein 1; ubiquitin-like PHD and RING finger domain-containing protein 1; TDRD22; RING-type E3 ubiquitin transferase UHRF1; RING finger protein 106; nuclear zinc finger protein Np95; nuclear protein 95; Np95; inverted CCAAT box-binding protein of 90 kDa; ICBP90; huNp95; hUHRF1; hNP95; E3 ubiquitin-protein ligase UHRF1; transcription factor ICBP90; nuclear phosphoprotein 95 |
| Gene, Accession # | Gene ID: 29128, Accession: NP_001041666.1, UniProt: Q96T88 |
| Catalog # | A301-470A |
| Price | $433 |
| Order / More Info | NP95/UHRF1 Antibody from FORTIS LIFE SCIENCES |
| Product Specific References | n/a |
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