IWS1 Antibody from FORTIS LIFE SCIENCES
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| Antigenic Specificity | IWS1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, (presumed: rat) |
| Isotype | n/a |
| Format | antigen affinity purified |
| Size | 10 µl |
| Concentration | 1000 µg/ml |
| Applications | WB, IP |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit anti-IWS1 Antibody, Affinity Purified. IWS1 homolog is a transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. IWS1 acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96ST2]. |
| Immunogen | Epitope: between 1 and 50 |
| Other Names | interacts with Spt6; IWS1 homolog; IWS1-like protein; protein IWS1 homolog |
| Gene, Accession # | Gene ID: 55677, Accession: NP_060439.2, UniProt: Q96ST2 |
| Catalog # | A304-609A-T |
| Price | $121 |
| Order / More Info | IWS1 Antibody from FORTIS LIFE SCIENCES |
| Product Specific References | n/a |
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