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Antigenic Specificity | VRK1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 10 µl |
Concentration | 1000 µg/ml |
Applications | IP |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit anti-VRK1 Antibody, Affinity Purified. Vaccinia-related kinase 1 is a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases.VRK1 is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This protein, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN [taken from NCBI Entrez Gene (Gene ID: 7443)]. |
Immunogen | Epitope: between 1 and 50 |
Other Names | PCH1A; vaccinia virus B1R-related kinase 1; Vaccinia-related kinase 1; PCH1; serine/threonine-protein kinase VRK1; vaccinia related kinase 1 |
Gene, Accession # | Gene ID: 7443, Accession: NP_003375.1, UniProt: Q99986 |
Catalog # | A305-268A-T |
Price | $121 |
Order / More Info | VRK1 Antibody from FORTIS LIFE SCIENCES |
Product Specific References | n/a |