Exportin-5 Antibody from FORTIS LIFE SCIENCES
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| Antigenic Specificity | Exportin-5 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | antigen affinity purified |
| Size | 10 µl |
| Concentration | 1000 µg/ml |
| Applications | WB, IP, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit anti-Exportin-5 Antibody, Affinity Purified. Exportin-5 mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). Exportin-5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. Exportin-5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9HAV4]. |
| Immunogen | Epitope: between 1154 and 1204 |
| Other Names | ran-binding protein 21; exp5; exportin-5 |
| Gene, Accession # | Gene ID: 57510, Accession: NP_065801.1, UniProt: Q9HAV4 |
| Catalog # | A303-991A-T |
| Price | $121 |
| Order / More Info | Exportin-5 Antibody from FORTIS LIFE SCIENCES |
| Product Specific References | n/a |
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