METTL14 Antibody from FORTIS LIFE SCIENCES
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| Antigenic Specificity | METTL14 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, (presumed: mouse, Xenopus laevis, Xenopus tropicalis, bovine, orangutan) |
| Isotype | n/a |
| Format | antigen affinity purified |
| Size | 100 µl |
| Concentration | 1000 µg/ml |
| Applications | WB, IP |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit anti-METTL14 Antibody, Affinity Purified. METTL14 forms a heterodimer with METTL3, creating an N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9HCE5]. |
| Immunogen | Epitope: between 25 and 75 |
| Other Names | hMETTL14; methyltransferase-like protein 14; N6-adenosine-methyltransferase non-catalytic subunit; N6-adenosine-methyltransferase subunit METTL14 |
| Gene, Accession # | Gene ID: 57721, Accession: NP_066012.1, UniProt: Q9HCE5 |
| Catalog # | A305-847A |
| Price | $433 |
| Order / More Info | METTL14 Antibody from FORTIS LIFE SCIENCES |
| Product Specific References | n/a |
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