Edit |   |
---|---|
Antigenic Specificity | NEDD4L |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, (presumed: orangutan) |
Isotype | n/a |
Format | antigen affinity purified |
Size | 100 µl |
Concentration | 200 µg/ml |
Applications | WB, IP, IHC |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit anti-NEDD4L Antibody, Affinity Purified. NEDD4L (neural precursor cell expressed, developmentally down-regulated 4-like) functions as an E3 ubiquitin-protein ligase. NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. It also promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5 [taken from the Universal Protein Resource (UniProt) wwwuniprotorg/uniprot/Q96PU5]. |
Immunogen | Epitope: between 275 and 325 |
Other Names | E3 ubiquitin-protein ligase NEDD4-like; PVNH7; RSP5; ubiquitin-protein ligase Rsp5; NEDD4.2; HECT-type E3 ubiquitin transferase NED4L; hNEDD4-2; NEDD4-2 |
Gene, Accession # | Gene ID: 23327, Accession: NP_001138439.1, UniProt: Q96PU5 |
Catalog # | A302-513A |
Price | $433 |
Order / More Info | NEDD4L Antibody from FORTIS LIFE SCIENCES |
Product Specific References | n/a |