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Antigenic Specificity | Menin |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, (presumed: rat, bovine, dog) |
Isotype | n/a |
Format | antigen affinity purified |
Size | 100 µl |
Concentration | 1000 µg/ml |
Applications | WB, IP, IHC |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit anti-Menin Antibody, Affinity Purified. Menin is the gene product of the putative tumor suppressor MEN1 associated with the syndrome termed multiple endocrine neoplasia type 1 that may function in the regulation of DNA synthesis or the response to DNA damage. Menin has been shown to interact with JunD, a member of the AP-1 heterodimer and inhibit transcription. Menin has also been shown to interact with Pem, FANCD2, RPA, NMMHCII-A, GFAP, vimentin, Hsp70, NfkappaB proteins, Smads, mSin3A and is part of the MLL2 and MLL1 Set1-like histone H3 K4 methyltransferase complex where it interacts directly with ASH2, Rbbp5, and WDR5. As part of the MLL complexes, menin may mediate its tumor suppressor activity via the regulation of histone methylation of HOX and CDK inhibitor genes. Alternative names for Menin are MEAI, multiple endocrine adenomatosis 1, suppressor Candidate Gene 2, and SCG2. |
Immunogen | Epitope: between 575 and C-term |
Other Names | MEAI; menin; SCG2 |
Gene, Accession # | Gene ID: 4221, Accession: NP_570711.1, UniProt: O00255 |
Catalog # | A300-105A |
Price | $433 |
Order / More Info | Menin Antibody from FORTIS LIFE SCIENCES |
Product Specific References | n/a |