STING/TMEM173 Antibody from FORTIS LIFE SCIENCES
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| Antigenic Specificity | STING/TMEM173 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | antigen affinity purified |
| Size | 10 µl |
| Concentration | 1000 µg/ml |
| Applications | WB, IP |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit anti-STING/TMEM173 Antibody, Affinity Purified. STING/TMEM173 is a facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Essential for the induction of IFN-beta in response to human herpes simplex virus 1 (HHV-1) infection. Exhibits 2',3' phosphodiester linkage-specific ligand recognition. Can bind both 2'-3' linked cGAMP and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q86WV6]. |
| Immunogen | Epitope: between 329 and 379 |
| Other Names | SAVI; Transmembrane protein 173; TMEM173; STING-beta; STING; stimulator of interferon genes protein; N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner; NET23; mitochondrial mediator of IRF3 activation; MITA; Mediator of IRF3 activation; hSTING; hMITA; ERIS; endoplasmic reticulum interferon stimulator; endoplasmic reticulum IFN stimulator; MPYS; stimulator of interferon protein |
| Gene, Accession # | Gene ID: 340061, Accession: NP_938023.1, UniProt: Q86WV6 |
| Catalog # | A305-852A-T |
| Price | $121 |
| Order / More Info | STING/TMEM173 Antibody from FORTIS LIFE SCIENCES |
| Product Specific References | n/a |
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