COBRA1 Antibody from FORTIS LIFE SCIENCES

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Antigenic SpecificityCOBRA1
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
Formatantigen affinity purified
Size10 µl
Concentration250 µg/ml
ApplicationsIHC, IHC-IF
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DescriptionRabbit anti-COBRA1 IHC Antibody, Affinity Purified. COBRA1 (Cofactor of BRCA1) is also known as NELFB (negative elongation factor E). NELFB is one of four subunits that make up the NELF transcription elongation factor. The four subunits of NELF are NELF A (WHSC2), NELFB, either NELFC or NELFD, and NELFE. NELF, along with DRB sensitivity-inducing factor (DSIF), functions to cause transcriptional pausing of RNA polymerase II. COBRA1 was originally identified in a yeast two-hybrid screen of a human ovary cDNA library using the BRCA COOH terminus repeat, BRCT1, as the bait protein. In this study, COBRA1 was found to be involved in BRCT1-mediated chromatin remodeling. COBRA1 has also been found to interact with several nuclear receptors such as ERalpha and androgen receptor to modulate their transcriptional activity.
ImmunogenEpitope: between 530 and 580
Other Namescofactor of BRCA1; negative elongation factor B; negative elongation factor protein B; NELF-B; COBRA1
Gene, Accession #Gene ID: 25920, Accession: NP_056271.3, UniProt: Q8WX92
Catalog #IHC-00384-T
Price$121
Order / More InfoCOBRA1 Antibody from FORTIS LIFE SCIENCES
Product Specific Referencesn/a
FORTIS LIFE SCIENCES
FORTIS LIFE SCIENCES
FORTIS LIFE SCIENCES
1440 Main Street, Suite 300
Waltham MA 02451
P: 800.338.9579

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