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Antigenic Specificity | TOPORS |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 10 µl |
Concentration | 200 µg/ml |
Applications | WB, IP, IHC |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit anti-TOPORS Antibody, Affinity Purified. TOPORS (topoisomerase I-binding RS protein) was identified in a a yeast two-hybrid screen for proteins that bind the N-terminus of topoisomerase I. TOPORS contains a RING-type zinc-finger domain and an RS-rich region. TOPORS has been found to possess both ubiquitin and SUMO-1 E3 ligase activity. It can ubiquitinate and sumoylate p53 and may possibly function as a tumor suppressor. Defects in TOPORS are the cause of retinitis pigmentosa type 31. |
Immunogen | Epitope: between 995 and 1045 |
Other Names | topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase Topors; tumor suppressor p53-binding protein 3; TP53BPL; topoisomerase I-binding RING finger protein; Topoisomerase I-binding arginine/serine-rich protein; RP31; RING-type E3 ubiquitin transferase Topors; P53BP3; LUN; p53-binding protein 3; SUMO1-protein E3 ligase Topors |
Gene, Accession # | Gene ID: 10210, Accession: NP_005793.2, UniProt: Q9NS56 |
Catalog # | A302-179A-T |
Price | $121 |
Order / More Info | TOPORS Antibody from FORTIS LIFE SCIENCES |
Product Specific References | n/a |