PBRM1 Antibody from FORTIS LIFE SCIENCES
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| Antigenic Specificity | PBRM1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | antigen affinity purified |
| Size | 10 µl |
| Concentration | 1000 µg/ml |
| Applications | WB, IP, IHC |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit anti-PBRM1 Antibody, Affinity Purified. The SMARCs (SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin), and BAFs (BRG1-associated factors), have been identified as components of the mammalian SWI/SNF-like chromatin-remodeling protein complexes. These multi-protein complexes are proposed to function as ATP-driven motors that translocate along DNA and destabilize nucleosomal structures to facilitate transcription factor binding. PBRM1 is a component of the SWI/SNF-B (PBAF) complex. It contains six bromodomains which are defined by a 110 amino-acid module that interacts with acetylated lysine and is found in many chromatin binding proteins and histone acetyltransferases. PBRM1 has been proposed to function as a tumor suppressor protein. Recently, PBRM1 has been found to play a role in mediating cell cycle arrest in response to DNA damage via the regulation of the tumor suppressor p21. |
| Immunogen | Epitope: between 1639 and 1689 |
| Other Names | BAF180; protein polybromo-1; polybromo-1D; PB1; BRG1-associated factor 180; hPB1 |
| Gene, Accession # | Gene ID: 55193, Accession: NP_060783.3, UniProt: Q86U86 |
| Catalog # | A301-591A-T |
| Price | $121 |
| Order / More Info | PBRM1 Antibody from FORTIS LIFE SCIENCES |
| Product Specific References | n/a |
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