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Antigenic Specificity | CSN3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 10 µl |
Concentration | 250 µg/ml |
Applications | IHC |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit anti-CSN3 IHC Antibody, Affinity Purified. CSN3 is one of eight subunits (CSN1 to 8) of the highly conserved COP9 signalsome (CSN) complex originally identified as a regulator of light-mediated development in Arabidopsis. Characterization of CSN from yeast to mammals reveals its function as a modulator of signal transduction pathways involved in a variety of cellular and developmental processes. One of the major functions of the CSN is the regulation of protein degradation via intersection with the ubiquitin-proteasome pathway and regulation of E3-ubiquitin ligases. The CSN also possesses kinase activity. CSN3 is the kinase associated with the CSN complex that phosphorylates signal transducers such as I-kappa-Balpha, p105, and c-Jun. Human CSN3 maps to the Smith-Magenis syndrome locus. Microdeletions in this locus results in mental retardation, skeletal abnormalities, sleep disorder, and neurobehavior anomalies. |
Immunogen | Epitope: between 325 and 375 |
Other Names | SGN3; signalosome subunit 3; JAB1-containing signalosome subunit 3; COP9 signalosome complex subunit 3; COP9 constitutive photomorphogenic homolog subunit 3; COP9 complex subunit 3; CSN3 |
Gene, Accession # | Gene ID: 8533, Accession: NP_003644.2, UniProt: Q9UNS2 |
Catalog # | IHC-00111-T |
Price | $121 |
Order / More Info | CSN3 Antibody from FORTIS LIFE SCIENCES |
Product Specific References | n/a |