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Antigenic Specificity | MERIT40 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, (presumed: orangutan) |
Isotype | n/a |
Format | antigen affinity purified |
Size | 10 µl |
Concentration | 1000 µg/ml |
Applications | IP |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit anti-MERIT40 Antibody, Affinity Purified. MERIT40 (mediator of RAP80 interactions and targeting subunit of 40 kDa) is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites and leads to targeting of the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. MERIT40 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NWV8]. |
Immunogen | Epitope: between 1 and 50 |
Other Names | C19orf62; new component of the BRCAA1 A complex; new component of the BRCA1-A complex; NBA1; MERIT40; mediator of RAP80 interactions and targeting subunit of 40 kDa; HSPC142; BRISC and BRCA1-A complex member 1; BRCA1-A complex subunit MERIT40; mediator of Rap80 interactions and targeting 40 kDa |
Gene, Accession # | Gene ID: 29086, Accession: NP_054892.2, UniProt: Q9NWV8 |
Catalog # | A302-515A-T |
Price | $121 |
Order / More Info | MERIT40 Antibody from FORTIS LIFE SCIENCES |
Product Specific References | n/a |