NISCH Antibody from FORTIS LIFE SCIENCES
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| Antigenic Specificity | NISCH |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | antigen affinity purified |
| Size | 100 µl |
| Concentration | 1000 µg/ml |
| Applications | IP |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit anti-NISCH Antibody, Affinity Purified. Nischarin (NISCH) is a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of NISCH was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation[taken from NCBI Entrez Gene (Gene ID: 11188)]. |
| Immunogen | Epitope: between 1100 and 1150 |
| Other Names | I1R; IRAS; IR1; Imidazoline-1 receptor candidate protein; Imidazoline receptor antisera-selected protein; Imidazoline-1 receptor; nischarin; I1R candidate protein; I-1 receptor candidate protein; I-1; hIRAS; imidazoline receptor 1; imidazoline receptor antisera selected |
| Gene, Accession # | Gene ID: 11188, Accession: NP_009115.3, UniProt: Q9Y2I1 |
| Catalog # | A305-446A |
| Price | $433 |
| Order / More Info | NISCH Antibody from FORTIS LIFE SCIENCES |
| Product Specific References | n/a |
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