PAN3 Antibody from FORTIS LIFE SCIENCES
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| Antigenic Specificity | PAN3 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | antigen affinity purified |
| Size | 100 µl |
| Concentration | 1000 µg/ml |
| Applications | WB, IP |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit anti-PAN3 Antibody, Affinity Purified. PAB-dependent poly(A)-specific ribonuclease subunit PAN3 is a regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with PABP and to miRNA targets via its interaction with GW182 family proteins [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q58A45]. |
| Immunogen | Epitope: between 175 and 225 |
| Other Names | PAN3 poly(A) specific ribonuclease subunit homolog; poly(A)-nuclease deadenylation complex subunit 3; PAN2-PAN3 deadenylation complex subunit PAN3; PAN deadenylation complex subunit 3; PABP-dependent poly(A) nuclease 3; PAB-dependent poly(A)-specific ribonuclease subunit PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3; PAB1P-dependent poly(A)-specific ribonuclease; PAB1P-dependent poly(A)-nuclease; PABP1-dependent poly A-specific ribonuclease subunit PAN3 |
| Gene, Accession # | Gene ID: 255967, Accession: NP_787050.6, UniProt: Q58A45 |
| Catalog # | A304-914A |
| Price | $433 |
| Order / More Info | PAN3 Antibody from FORTIS LIFE SCIENCES |
| Product Specific References | n/a |
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