RBL1 Antibody from FORTIS LIFE SCIENCES
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| Antigenic Specificity | RBL1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, (presumed: mouse) |
| Isotype | n/a |
| Format | antigen affinity purified |
| Size | 10 µl |
| Concentration | 1000 µg/ml |
| Applications | IP |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit anti-RBL1 Antibody, Affinity Purified. Retinoblastoma-like protein 1 (RBL1) is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. RBL1 recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. It controls histone H4 'Lys-20' trimethylation. RBL1 probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. It is a potent inhibitor of E2F-mediated trans-activation. RBL1 forms a complex with adenovirus E1A and with SV40 large T antigen and may bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. RBL1 may act as a tumor suppressor [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P28749]. |
| Immunogen | Epitope: between 1018 and 1068 |
| Other Names | retinoblastoma-like 1; retinoblastoma-like protein 1; PRB1; p107; CP107; 107 kDa retinoblastoma-associated protein |
| Gene, Accession # | Gene ID: 5933, Accession: NP_899662.1, UniProt: P28749 |
| Catalog # | A305-672A-T |
| Price | $121 |
| Order / More Info | RBL1 Antibody from FORTIS LIFE SCIENCES |
| Product Specific References | n/a |
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