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Antigenic Specificity | ZEB1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 10 µl |
Concentration | 200 µg/ml |
Applications | WB, IP |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit anti-ZEB1 Antibody, Affinity Purified. ZEB1 (zinc-finger E-box-binding homeobox 1), also known as TCF8 (transcription factor 8), is a delta-EF1/ZFH-1 C2H2-type zinc finger that bears seven C2H2-type zinc fingers and one homeobox DNA-binding domain. ZEB1 is a transcriptional repressor of interleukin-2 (IL-2). Mutations in the ZEB1 gene are associated with posterior corneal dystrophy type 3 (PPC3) a rare disorder characterized by metaplasia and overgrowth of corneal endothelial cells. ZEB1 appears to be critical to epithelial to mesenchymal transitions (EMT) during development and cancer metastasis. As a transcription factor involved in EMT, ZEB1 promotes EMT by repressing genes associated with the epithelial phenotype and activates genes associated with the mesenchymal phenotype. |
Immunogen | Epitope: between 850 and 900 |
Other Names | PPCD3; posterior polymorphous corneal dystrophy 3; zinc finger homeodomain enhancer-binding protein; zinc finger E-box-binding homeobox 1; ZFHX1A; ZFHEP; transcription factor 8 (represses interleukin 2 expression); Transcription factor 8; TCF-8; AREB6; NIL-2-A zinc finger protein; NIL2A; negative regulator of IL2; FECD6; DELTAEF1; delta-crystallin enhancer binding factor 1; BZP; TCF8 |
Gene, Accession # | Gene ID: 6935, Accession: NP_110378.3, UniProt: P37275 |
Catalog # | A301-921A-T |
Price | $121 |
Order / More Info | ZEB1 Antibody from FORTIS LIFE SCIENCES |
Product Specific References | n/a |