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Antigenic Specificity | MCAK |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse, (presumed: rat) |
Isotype | n/a |
Format | antigen affinity purified |
Size | 100 µl |
Concentration | 1000 µg/ml |
Applications | WB, IP, IHC |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit anti-MCAK Antibody, Affinity Purified. Kinesin activity has been linked to various cellular functions such as vesicle transport, mitotic spindle formation, chromosome segregation, chromosome congression, and cytokinesis. Structurally, all kinesins contain a motor domain with microtubule and nucleotide binding sites that utilize ATP to target cargo along microtubule filaments. MCAK (Mitotic Centromere-Associated Kinesin) is the founding member of kinesin-13 proteins. There are 3 independent genes coding for kinesin-13 proteins kif2a, kif2b, and kif2c (MCAK). Instead of functioning as a translocator of microtubules MCAK is a depolymerizer that is primarily responsible for releasing improper microtubule-kinetochore attachments during cell division. |
Immunogen | Epitope: between 50 and 100 |
Other Names | Knsl6; X83316; mitotic centromere-associated kinesin; MCAK; kinesin-like protein KIF2C; kinesin-like 6; 4930402F02Rik; ESTM5 |
Gene, Accession # | Gene ID: 73804, Accession: NP_608301.3, UniProt: Q922S8 |
Catalog # | A300-921A |
Price | $433 |
Order / More Info | MCAK Antibody from FORTIS LIFE SCIENCES |
Product Specific References | n/a |