Edit |   |
---|---|
Antigenic Specificity | DIS3L2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 100 µl |
Concentration | 1000 µg/ml |
Applications | WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit anti-DIS3L2 Antibody, Affinity Purified. DIS3L2 is a 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8IYB7]. |
Immunogen | Epitope: between 475 and 525 |
Other Names | family with sequence similarity 6, member A; hDIS3L2; FAM6A; DIS3-like exonuclease 2; DIS3 mitotic control homolog-like 2; PRLMNS |
Gene, Accession # | Gene ID: 129563, Accession: NP_689596.4, UniProt: Q8IYB7 |
Catalog # | A305-859A |
Price | $433 |
Order / More Info | DIS3L2 Antibody from FORTIS LIFE SCIENCES |
Product Specific References | n/a |