RRP8 Antibody from FORTIS LIFE SCIENCES
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| Antigenic Specificity | RRP8 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | antigen affinity purified |
| Size | 10 µl |
| Concentration | 1000 µg/ml |
| Applications | IP |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit anti-RRP8 Antibody, Affinity Purified. Ribosomal RNA-processing protein (RRP8) is an essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O43159]. |
| Immunogen | Epitope: between 406 and 456 |
| Other Names | nucleomethylin; RRP8 methyltransferase homolog; cerebral protein 1; ribosomal RNA processing 8, methyltransferase, homolog; NML; KIAA0409; ribosomal RNA-processing protein 8 |
| Gene, Accession # | Gene ID: 23378, Accession: NP_056139.1, UniProt: O43159 |
| Catalog # | A304-202A-T |
| Price | $121 |
| Order / More Info | RRP8 Antibody from FORTIS LIFE SCIENCES |
| Product Specific References | n/a |
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